Research Overview (publications)
Dr. Tang’s laboratory has focused on two related research areas. One is to determine the structures and dynamics of neurotransmitter-gated ion channels, which play a central role in neuron signaling and are targets of therapeutics. Another is to understand channel protein interactions with low-affinity drugs, particularly general anesthetics and alcohols. Various biophysical tools, including high-resolution nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, as well as large-scale molecular dynamic simulations, have been utilized to tackle various biomedical and neuroscience questions.
Projects
- Structural basis of neurosteroid anesthetic action on GABAA receptors
- Recent progress on the molecular pharmacology of propofol
News/Media Appearances
Lab Members
Principal Investigator: Pei Tang, PhD
Research Instructor: Vasyl Bondarenko, PhD
Research Assistant Professor: Qiang "Charles" Chen, PhD
Lab Contact Info
Pei Tang, PhD
Office Phone: 412-383-9798
Lab Phones: 412-648-2945
412-648-9137
412-648-9024
Fax:
412-648-8998