Tang Lab News

The research team of Pei Tang, PhD, identified a helical motif in the SARS-CoV-2 spike neck that is responsible for α7nAChR downregulation.

A paper from the lab of Pei Tang, PhD, “Structures of Highly Flexible Intracellular Domain of Human α7 Nicotinic Acetylcholine Receptor,” was published in the high-impact journal Nature Communications.

A paper from the labs of Yan Xu, PhD, and Pei Tang, PhD, in partnership with collaborators at Temple University, University of Pennsylvania, and Shanghai Jiaotong University, was published this month in the journal Proceedings of the National Academy of Sciences.

They were recognized for their abstract “Preclinical Evaluation of a Novel Glycinergic Analgesic for Treatment of Chronic Pain in Rodents.”

The Journal of General Physiology research news article “Propofol’s paradox, explained” spotlights a publication on work from the labs of Yan Xu, PhD, and Pei Tang, PhD.

"Structural basis of neurosteroid anesthetic action on GABA(A) receptors" was published in the renowned open-access journal Nature Communications.

The study theorizes that the process of consciousness and loss of consciousness under anesthesia can be likened to the flow of water through coffee grounds.

“Cellular Registration without Behavioral Recall of Olfactory Sensory Input under General Anesthesia” reveals new findings that suggest the brain receives and registers sensory information at the cellular level while anesthetized without behavioral reporting of the same information after recovering from anesthesia.

In their paper, the authors show that acetylcholine is a competitive antagonist for ELIC, the pentameric ligand-gated ion channel from the bacteria Erwinia chrysanthemi.

“NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor” was published as the cover story in the March issue of Biochimica et Biophysica Acta Biomembranes.