Grace Lim, MD, MS, is a board-certified obstetric (OB) anesthesiologist and physician scientist dedicated to eliminating suffering in special populations, medication safety in pregnancy and lactation, and patient safety through innovative, personalized care. She accomplishes these goals using a mix of clinical and translational approaches including individualized (e.g., genetic, liquid biopsy, pharmacokinetic, patient-reported, quantitative sensory) and population-based (e.g., large administrative data sets, integrated electronic health record analyses) methods, gaining a holistic understanding of a health problem from both a population and personalized perspective.
As Chief of the Division of OB & Women’s Anesthesiology at UPMC, Dr. Lim has expanded high-quality OB anesthesia services and advanced multidisciplinary perinatal care. Her leadership has influenced national guidelines in OB anesthesiology and earned her roles on the Board of Directors for the Society for Obstetric Anesthesia and Perinatology (SOAP), as well as advisory positions with the American College of Obstetricians and Gynecologists (ACOG), the Alliance for Innovation in Maternal Health (AIM), and the American Society of Anesthesiologists (ASA).
Dr. Lim’s research, funded by the NIH, PCORI, and institutional grants, focuses on peripartum pain mechanisms, opioid-sparing analgesic strategies, and optimizing maternal safety. Her studies explore neurobiological mechanisms of labor pain, postpartum pain trajectories, and the impact of pain management on maternal-infant health. She has led clinical trials and contributed to national guidelines on labor pain management for individuals with opioid use disorder.
Her quality improvement initiatives at UPMC include Enhanced Recovery After Cesarean (ERAC) protocols, nitrous oxide labor analgesia, and postpartum hemorrhage and analgesia bundles. She has driven reductions in anesthesia-related maternal morbidity and developed opioid-sparing multimodal analgesia protocols.
An academic leader, Dr. Lim mentors NIH-funded trainees, contributes to medical education, and has authored influential textbooks and research publications. She is a sought-after speaker internationally and at leading institutions, including Harvard, Stanford, and the Mayo Clinic.
- University of Missouri, Combined BA/MD
- Northwestern University Feinberg School of Medicine, Anesthesiology Residency
- Northwestern University Feinberg School of Medicine, Obstetric Anesthesiology Fellowship
- University of Pittsburgh, NIH NRSA T32 Postdoctoral Research Fellowship
- University of Pittsburgh Institute for Clinical Research Education, Master of Science in Clinical Research (MSci), Comparative Effectiveness Track
Education & Training
Dr. Lim's publications can be reviewed through the National Library of Medicine's publication database.
Clinical and translational research in obstetric and women’s anesthesiology at UPMC Magee-Womens Hospital seeks to optimize women’s health, maternal and neonatal health by developing novel, personalized, and patient-centered clinical management strategies. Research from the Lim lab continues to focus on the primary themes of OB anesthesia and perinatology, perinatal mood disorders and pain, and outcomes optimization in special populations.
Selected Noncomprehensive List of Current Funding
- “Elevating Anesthesia Choices for Cesarean Delivery: A Roadmap to Patient-Centered Research,” PCORI EASCS-34606, PI: Lim, 6/2024-5/2025: This Stakeholder Convening Support award will be the first step towards filling the crucial gap of lack of good evidence to guide decisions about cesarean delivery anesthesia that balances patient centered outcomes with maternal-neonatal safety and health.
- “Observational Trial Defining PPH Phenotypes using Viscoelastic Testing Duration,” Octapharma, PI: Lim, 1/2024-1/2025: This research will establish a strong trial network infrastructure and provide crucial insights into the use of fibrinogen concentrate in PPH patients.
- “Ketamine to reduce postpartum depression and pain after cesarean delivery,” NIMH R01MH134538, PI: Lim, 7/01/2023 – 7/11/2028: Postpartum depression (PPD) affects 28 million mothers worldwide annually and there are no effective preventative therapies. These investigations will identify a patient-informed acceptable dose and pharmacokinetics of ketamine infusion after cesarean delivery, a common mode of birth, and will provide novel data on trajectories of PPD symptoms after CD. The results of these investigations will inform optimal dosing strategies for postpartum ketamine.
- “Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain,” NIH/NINDS UH3CA261067 (Doan, Wang) / Site PI, 9/17/2021 – 9/16/2025: Phase III, three-arm, placebo-controlled, randomized (1:1:1) clinical trial that aims to study the effectiveness of ketamine in reducing post-mastectomy pain and determine the effect of infusion vs. single- bolus ketamine on pain, function, and mood
Selected Noncomprehensive List of Completed Funding
- "Reducing Pain's Impact on Perinatal Depression" (Lim) / PI, CTSI Pain Research Challenge/Virginia Kaufman Award, PI, 2016 – 2017
- "Ketamine to Reduce the Burden of Postpartum: Lactation Pharmacokinetic Trial (KINETIC)" (Lim) / PI, CTSI Pain Research Challenge/Virginia Kaufman Award, PI, 2018 – 2021
- "Quantifying Genetic Variation in Postpartum Women for Pain and Postpartum Depression" (Lim) / PI, UPitt – UGC Precision Medicine Pilot Grants, PI, 2018 – 2020
- "BRIDGE Device: Alternative Postpartum Analgesia" (Lim) / PI, CTSI Research Initiative for Special Populations (CRISP), PI, 2020 – 2021
- "Obstetric pain management for women with opioid use disorder: A longitudinal, qualitative mixed-methods evaluation of patients and provider perspectives" (Lim) / PI, CTSI Research Initiative for Special Populations (CRISP), PI, 2020 - 2021
- “Labor Pain and Maternal, Infant, and Parent-Infant Psychological and Psychosocial Health” (Lim) / PI, University of Pittsburgh Physicians (UPP) Academic Foundation, PI, 2015-2017